Mario Urrutia had five catches for 110 yards and a touchdown, and the Cardinals finished with 671 yards of total offense - the fifth-highest total in school history. The winning margin on the road was the third-highest in team history.
With a game against Miami next week, the lowly Owls (0-2) were a perfect tuneup for the redesigned backfield now that Bush is lost for the season with a broken leg. Bush led the nation in scoring last year, averaging 14.4 points per game while scoring a school-record 23 touchdowns, but was injured on the second play of the second half in the opener against Kentucky.
While they all run against a tougher defense in practice, Smith had 86 yards rushing, and Stripling and Spencer each had 72 before sitting out most of the fourth quarter. They even used their speed to turn short catches into long gains and set up scores.
On fourth-and-4 at the Louisville 39 late in the first half, Stripling turned a catch in the flat into a 43-yard gain down the right sideline. Two plays later, Spencer scored on a 1-yard run for a 42-0 lead.
Yes, 42-0. With 443 yards of total offense. At the half. On the road.
Then again, the Owls are overmatched against most teams. Temple, which went 0-11 last year, has lost 14 straight. The Owls lost seven games last year by more than 30 points, including two losses of more than 60.
The Owls best shot to score their first touchdown of the season came late in the third when Jason Harper's 67-yard reception took the ball down to the 2. But on the next play, the Owls lost a fumble.
Playing in front of a sparse crowd in their home opener, the Owls managed a stop and an interception on Louisville's first two possession. Then, predictably, the game fell apart.
Smith scored on a 3-yard run on the Cardinals' third drive and they needed only two plays on their next possession for Brohm to connect with Urrutia for a 57-yard score.
Quarterman added a 1-yard run and Stripling had TD runs of 17 and 3 yards in the half.
Spencer made it 49-0 with a 4-yard run early in the third. With a lopsided score and Bush's injury still fresh, Brohm was pulled for good with 5 minutes left in the third quarter.
Art Carmody kicked field goals of 23 and 51 yards, and Deriontae Taylor rushed for a 1-yard TD in the fourth.