Spaziani, who coach the Eagles to a victory at the 2006 Meineke Car Care Bowl after O'Brien bolted for NC State, worked under O'Brien for all of his 10 seasons at BC.
The two coached together for 26 years in total, also under George Welsh at Navy and Virginia. Spaziani became BC's head coach after Jeff Jagodzinski was fired last winter for interviewing for an NFL vacancy.
BC, which led 24-13 at halftime, broke it open by taking the ball on the first possession of the second half and marching 72 yards in 11 plays, with Harris capping it with a 10-yard TD run.
Harris had 46-yard run to push him over 200 yards and set up his own score, a 1-yarder two plays later, making it 38-13. He added a 29-yard TD run late in the third quarter, improving it to 45-13.
BC quarterback Dave Shinskie threw a 59-yard scoring pass to Colin Larmond Jr. in the first quarter and finished 13 of 25 for 187 yards with two TD passes.
NC State QB Russell Wilson had a 1-yard scoring run and was 23 of 40 for 243 yards with one TD.
The Wolfpack were allowing just 62.8 yards per game on the ground entering the game, but Harris wiped that out on one run early in the game.
On its second series, Boston College went to the ``Wildcat'' formation and Harris busted through the line and down the right sideline for a 70-yard gain, moving the ball to the 2. He scored on the next play, making it 7-0.
The Eagles used the ``Wildcat'' with Harris at QB a number of times in the third quarter.
NC State tied it 7-7 on Wilson's 1-yard TD plunge.
BC answered right back when Shinskie hit Larmond Jr. to make it 14-7. Larmond Jr. leaped over cornerback Rashard Smith near the 13-yard line to catch the slightly under-thrown ball before heading to the end zone.
NC State's Josh Czajkowski had field goals of 25 and 32 yards to cut to 14-13.
The Eagles made it 21-13 on Harris' 12-yard TD run late in the second.
BC's Steve Aponavicius kicked a 37-yard field goal as time expired in the first half.
The Eagles play at Notre Dame next Saturday. NC State is off next week before traveling to Florida State on Halloween.