The Commodores closed the first half on a 15-2 run, and cruised for most of the second half, leading 58-35 at one point. A late Crimson Tide run keyed by VU's turnovers helped 'Bama cut the lead to 10 at the end.
Vandy shot just 40 percent from the field, took 20 fewer shots that Alabama, and committed 17 turnovers to the 'Tide's eight. But a 13-rebound edge, a 14-point advantage at the foul line, and 'Bama's season-low 32.9 percent shooting put the Commodores over the top.
Alabama's leading scorer, Tony Mitchell, was held scoreless on eight shots.
UA had won 26 of its last 27 games at home.
Vanderbilt returns home to face Mississippi State on Saturday.